GLP-1 Drugs and Aging: Outcome Trials vs the Longevity Hype
Semaglutide cut heart and kidney events in large RCTs, then failed in Alzheimer's. What GLP-1 receptor agonists can and cannot claim as aging drugs.
Supplements
Cardiovascular
3 articles on Cardiovascular by Julian Douwes, M.D.: CoQ10 for Heart Health: What the Clinical Evidence Actually Shows; and more.
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SGLT2 Inhibitors for Longevity: What the Evidence Says About Empagliflozin and Dapagliflozin
SGLT2 inhibitors extend lifespan in animal models and reduce all-cause mortality in humans. Here is what the evidence shows—and how they fit alongside rapamycin and metformin.
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Trimethylglycine (TMG/Betaine): Methylation Support, Homocysteine, and Longevity
TMG donates methyl groups to lower homocysteine, support liver function, and enhance athletic performance. Clinical dosing, evidence, and who benefits most.
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Lipoprotein(a): The Cardiovascular Risk Factor Your Doctor May Be Missing
Lp(a) is an inherited, largely modifiable cardiovascular risk factor affecting 1 in 5 people. Learn how to test, interpret, and manage elevated Lp(a) levels.
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Sauna and Cardiovascular Health: What the Evidence Shows
Finnish sauna research links regular use to 40–63% lower cardiovascular mortality. Here's what the data shows, optimal protocols, and who should avoid it.
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Grip Strength as a Longevity Biomarker: What Your Handshake Predicts About Mortality
Grip strength is one of the most powerful predictors of all-cause mortality, cardiovascular disease, and cognitive decline. Here is what the evidence shows and what to do about it.
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L-Citrulline vs L-Arginine: Nitric Oxide, Cardiovascular Health, and Performance
A physician's clinical guide to nitric oxide precursors — how L-citrulline outperforms L-arginine for blood pressure, endothelial function, erectile health, and exercise recovery.
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ApoB vs LDL-C: Why Your Cholesterol Test May Be Missing Your Real Cardiovascular Risk
ApoB counts every atherogenic particle in your blood. LDL-C only estimates one fraction. Here is why the distinction matters for longevity and cardiovascular prevention.
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Lumbrokinase vs Nattokinase: Which Fibrinolytic Enzyme Is Right for You?
Comparing lumbrokinase and nattokinase for fibrin clearance, biofilm disruption, post-COVID microclots, and cardiovascular health — with clinical dosing guidance.
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Infrared Sauna vs Traditional Finnish Sauna: What the Clinical Evidence Actually Shows
Infrared and Finnish saunas share key benefits but differ in mechanism and heat delivery. A physician compares cardiovascular data, HSP activation, detox claims, and when to choose which.
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Homocysteine: What Your Levels Mean and How to Lower Them
High homocysteine quietly damages blood vessels and the brain. A physician explains optimal ranges, root causes like MTHFR, and evidence-based ways to lower it.
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Serrapeptase vs Nattokinase: Which Fibrinolytic Enzyme Is Right for You?
A physician-led comparison of serrapeptase and nattokinase: mechanisms, clinical evidence, dosing, and which fibrinolytic enzyme fits your health goals.
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Astaxanthin: The Most Potent Antioxidant for Mitochondrial and Cardiovascular Health
A physician's guide to astaxanthin—6,000× more potent than vitamin C—with clinical evidence for heart health, neuroprotection, eye health, and longevity.
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Vitamin K2: The Missing Nutrient for Cardiovascular Health, Bone Density, and Calcium Metabolism
Physician guide to vitamin K2 (MK-4 vs MK-7): how it directs calcium away from arteries into bones, optimal dosing, and why most people are deficient.
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Taurine and Longevity: A Physician's Evidence Review
Dr. Julian Douwes examines taurine's role in aging, the landmark 2023 Science study, clinical dosing protocols, and who stands to benefit most.
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Resveratrol and Longevity: What the Clinical Evidence Actually Shows
A physician's review of resveratrol's SIRT1 activation, cardiovascular and neuroprotective data, bioavailability limits, and practical dosing for longevity.
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CoQ10 for Heart Health: What the Clinical Evidence Actually Shows
Cardiologist-reviewed guide to CoQ10 for heart failure, hypertension, and statin-related symptoms. Dosing, forms, and who benefits most.
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How Often Should You Sauna? What the Longevity Evidence Shows
Physician analysis of sauna frequency for longevity based on the Finnish cohort studies. How often, how long, what temperature, and who should avoid it.
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Contrast Therapy Protocol: Should You Sauna or Cold Plunge First?
Physician-guided contrast therapy protocol combining sauna and cold plunge. Optimal order, timing, temperatures, and what the cardiovascular evidence shows.
